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Long-term safety data
Long-term cardiac and vascular TEAEs
Tab Number 3
Tab Number 4
Tab Number 5
To learn more about select adverse reactions, including therapy management suggestions and dose adjustments, click here.
To manage fluid retention, monitor and manage patients using standards of care. Interrupt, dose reduce, or discontinue BOSULIF as necessary.
Patients with uncontrolled or significant cardiovascular disease, including prolonged QT interval, were excluded by protocol.2
Example
BOSULIF can cause cardiovascular toxicity including cardiac failure, left ventricular dysfunction, and cardiac ischemic events. Cardiac failure events occurred more frequently in previously treated adults than in those with newly diagnosed CML and were more frequent in patients with advanced age or risk factors, including previous medical history of cardiac failure. Cardiac ischemic events occurred in both previously treated adults and in those with newly diagnosed CML and were more common in adults with coronary artery disease risk factors, including history of diabetes, body mass index greater than 30, hypertension, and vascular disorders.2
In a single-arm study of adults with CML who were resistant or intolerant to prior therapy, cardiac failure was observed in 5.3% of patients and cardiac ischemic events were observed in 4.9% of patients treated with BOSULIF.2
Monitor patients for signs and symptoms consistent with cardiac failure and cardiac ischemia and treat as clinically indicated. Interrupt, dose reduce, or discontinue BOSULIF as necessary.2
Close monitoring, particularly in high-risk patients, and proactive management should be standard of care before starting therapy.3
Convenient once-daily dosing
Management considerations for selected adverse reactions associated with BOSULIF
To report an adverse event, please call 1-800-438-1985
Pfizer for Professionals 1-800-505-4426
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Adult and pediatric patients 1 year of age and older with chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML), newly-diagnosed or resistant or intolerant to prior therapy
BOSULIF is indicated for the treatment of:
Adult and pediatric patients 1 year of age and older with chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML), newly-diagnosed or resistant or intolerant to prior therapy